Beilstein J. Org. Chem.2023,19, 448–473, doi:10.3762/bjoc.19.35
provide the reader a nice overview. Since reviews dealing with transition-metal-catalyzed functionalization of compounds by C–H bond activation with fluorinatedreagents [60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] and vinylic, allylic or propargylic fluorinated building blocks
PDF
Graphical Abstract
Scheme 1:
Transition-metal-catalyzed C–XRF bond formation by C–H bond activation: an overview.
Beilstein J. Org. Chem.2020,16, 1051–1065, doi:10.3762/bjoc.16.92
CF2SO2Ph motifs on a broad range of substrates. Copper-based fluorinatedreagents have the advantage of being inexpensive and generally in situ generated or prepared in a few steps, which make them convenient to use. In this review, an overview of the recent advances made for the synthesis of fluorinated
molecules using copper-based fluorinatedreagents will be given.
Keywords: copper; difluoromethylation; fluorinatedreagents; fluorine chemistry; synthetic methodologies; Introduction
In a society in which fluorinated molecules are playing a pivotal role in pharmaceutical and agrochemical industries as
-based fluorinatedreagents appeared over the years as a powerful tool in various transformations for the introduction of fluorinated moieties. Such strategy has already demonstrated a significant synthetic value for the trifluoromethylation of various compounds [16][17][18][19][20][21][22][23][24][25
PDF
Graphical Abstract
Scheme 1:
Synthesis of the first isolable (NHC)CuCF2H complexes from TMSCF2H and their application for the sy...